Endocrine Abstracts

Introduction: Signalling lymphocytic activation molecule SLAMF1 (CD150) is a modulatory receptor expressed in most immune cells. Different data indicate that CD150 is involved in T cell cytokine production, NK cell and CD8 T cell mediated cytotoxicity, and T regulatory (Treg) cell activity. Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function CD150 in lymphocytes subpopulations from p...

Introduction: Patients with autoimmune thyroid disease (AITD) exhibit aberrant immune-regulatory mechanisms. Galectins (Gal) are a family of glycan-binding proteins, which have been involved in immune regulation. However, the association of Gal with AITD remains unknown. In this study, we evaluated serum Gal-1 and Gal-9 in patients with AITD.Methods: Peripheral blood samples from 31 patients with Graves’ disease (GD) (14 with untreated hyperthyroidi...